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M9460241.TXT
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1994-06-12
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Document 0241
DOCN M9460241
TI Perioperative allogeneic blood transfusion exacerbates surgical
stress-induced postoperative immunosuppression and has a negative effect
on prognosis in patients with gastric cancer.
DT 9408
AU Maeta M; Shimizu N; Oka A; Kondo A; Yamashiro H; Tsujitani S; Ikegchi M;
Kaibara N; First Department of Surgery, Tottori University School of;
Medicine, Yonago, Japan.
SO J Surg Oncol. 1994 Mar;55(3):149-53. Unique Identifier : AIDSLINE
MED/94231771
AB The immunomodulative effect of perioperative allogeneic blood
transfusion on host immunocompetence was studied in 109 patients with
gastric cancer at various stages. Mitogen-induced lymphocyte
blastogenesis, lymphocyte surface markers (specific for T, B, CD4, and
CD8 populations), and the activity of natural killer (NK) cells were
examined before surgery and then 2 and 4 weeks after surgery. The
effects on host immunocompetence of transfusion alone, in the absence of
any effect of surgical stress, were studied, preoperatively, in nine
patients who received preoperative transfusion. Although a tendency
towards a decrease in the posttransfusion activity of NK cells was
observed, there were no statistically significant differences between
pre- and posttransfusion levels. Mitogen-induced blastogenesis and the
activity of NK cells were significantly impaired 2 weeks after surgery
in transfused patients as compared to those in nontransfused patients
with gastric cancer at stage III and stage IV, and postoperative
survival was significantly lower in transfused as compared to
nontransfused patients. These results indicate that perioperative
allogeneic blood transfusion exacerbates surgical stress-induced
postoperative immunosuppression and has a negative effect on prognosis
in patients with gastric cancer.
DE Blood Transfusion/*ADVERSE EFFECTS Comparative Study CD4-CD8 Ratio
Human Immunocompetence/PHYSIOLOGY Immunocompromised Host/*IMMUNOLOGY
Killer Cells, Natural/IMMUNOLOGY Lymphocyte Transformation/IMMUNOLOGY
Postoperative Complications/*IMMUNOLOGY Prognosis Stomach
Neoplasms/*IMMUNOLOGY/MORTALITY/SURGERY Stress/*IMMUNOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).